Communications & Resources

Cardio Pod: Heart of the Matter

Episode 1: What is the Heart Failure Collaboratory?
Join Drs. Christopher O'Connor, JoAnn Lindenfeld, Mitchell Psotka, Scott Solomon, Mona Fiuzat, Bill Abraham, and Peter Carson as they introduce a novel concept known as the Heart Failure Collaboratory (HFC) and discuss how it can contribute to the field of heart failure research.

Episode 1: What is the Heart Failure Collaboratory?

Episode 2: Contemporary Challenges in HF Clinical Trial Design
Expert statisticians Janet Wittes and Eric Leifer join the podcast to discuss hazard ratios, the phenomenon of "hazard ratio drift", and other contemporary challenges in HF clinical trial design.

Episode 2: Contemporary Challenges in HF Clinical Trial Design

Episode 3: Statistical Considerations in Heart Failure Research
Janet Wittes, Eric Leifer, Bill Abraham, and Mitchell Psotka join the podcast to discuss all-things statistics. What is an estimand? How should we treat p-values?

Episode 3: Statistical Considerations in Heart Failure Research

Episode 4: The Intersection of Heart Failure and the Kidney
James Januzzi, Maria Rosa Costanzo, John Teerlink, Marv Konstam, Bill Abraham, and nephrologist Steven Coca join the podcast to discuss HF and AKI. How should we react to rising creatinine?

Episode 4: The Intersection of Heart Failure and the Kidney

Episode 5: Diversity in Heart Failure Clinical Trials
James Januzzi, Maria Rosa Costanzo, John Teerlink, Marv Konstam, Bill Abraham, and nephrologist Steven Coca join the podcast to discuss HF and AKI. How should we react to rising creatinine?

Episode 5: Diversity in Heart Failure Clinical Trials

Episode 6: Implications of the Advisory Committee Meetings for the Heart Failure Community
Drs. Peter Carson, JoAnn Lindenfeld, John Teerlink, Orly Vardeny, and Bill Abraham join Dr. Christopher O'Connor to discuss the implications of the FDA Advisory Committee meetings with special focus on three programs: TOPCAT (2:05), PARAGON-HF (15:53), and GALACTIC-HF (30:35).

Episode 6: Implications of the Advisory Committee Meetings for the Heart Failure Community

HFC in the news

2022 Awardees Recognized at HFSA Annual Scientific Meeting
Pictured above: Christopher O'Connor, John Teerlink, and Mark Drazner present Melvin Echols, Christabel Nyange with a site-based research award.

2022 Awardees Recognized at HFSA Annual Scientific Meeting

Ellis Unger Honored with HFC Lifetime Achievement Award
In Spring 2022, we were incredibly proud to honor Dr. Ellis Unger as the first-ever recipient of the HFC Lifetime Achievement Award!

Ellis Unger Honored with HFC Lifetime Achievement Award

HFC call to action featured in TCTMD
Dr. Silia DeFilippis speaks with Caitlin Cox on the importance of this work.
HFC Abstracts Presented at ACC.22
HFC's Matt Dimond presents Collaboratory work on Functional and Symptomatic Endpoints at ACC.22

HFC Abstracts Presented at ACC.22

HFC guidance on recruiting diverse populations highlighted in ACC newsletter
See full HFC guidance on "Publications" page.

HFC guidance on recruiting diverse populations highlighted in ACC newsletter

HFC/HFSA Research Award Nominations
Nominations for this year's site-based research awards are now closed.

HFC/HFSA Research Award Nominations

HFC Lean CRF

HFC Lean CRF: Hemodynamics

HFC Lean CRF: Hemodynamics

HFC Lean CRF: Short-Term Mechanical Circulatory Support (MCS) Module

HFC Lean CRF: Short-Term Mechanical Circulatory Support (MCS) Module

HFC Lean CRF: Echocardiography Module

HFC Lean CRF: Echocardiography Module

HFC Lean CRF: Magnetic Resonance Imaging Module

HFC Lean CRF: Magnetic Resonance Imaging Module

HFC Lean CRF: Expanded Laboratory Details

HFC Lean CRF: Expanded Laboratory Details

HFC Lean CRF: Durable Mechanical Circulatory Support (MCS) Module

HFC Lean CRF: Durable Mechanical Circulatory Support (MCS) Module

HFC Lean CRF: Electrocardiogram Details Module

HFC Lean CRF: Electrocardiogram Details Module

HFC Lean Case Report Form

HFC Lean Case Report Form

COVID-19 Resources

HFC COVID-19 Data Capture Form
Download the COVID-Like Illness CRF Template and the related JACC publication “Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel”.
HFC Letter - Impact of COVID-19
The mission of the HFC has focused largely on clinical trials, and the impact of COVID-19 on clinical research will be significant.

HFC Letter - Impact of COVID-19

Dear Friends and Colleagues,

The mission of the HFC has focused largely on clinical trials, and the impact of COVID-19 on clinical research will be significant. The FDA has issued the following guidance with suggestions and recommendations. We have offered to collect any questions not addressed in the guidance and pass them along on behalf of HFC members. We hope this will be helpful in answering the many questions we are all facing.

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/fda-guidance-conduct-clinical-trials-medical-products-during-covid-19-pandemic

Kind regards,

Mona Fiuzat, Chris O’Connor, JoAnn Lindenfeld, Bill Abraham, Mitch Psotka, Bram Zuckerman, Norman Stockbridge
Heart Failure Collaboratory Co-Chairs and Members

FDA guidance on statistical considerations for clinical trials during the pandemic
“Statistical Considerations for Clinical Trials During the COVID-19 Public Health Emergency Guidance for Industry”

FDA guidance on statistical considerations for clinical trials during the pandemic

NIH Guidance for NIH-funded Clinical Trials and Human Subjects Studies Affected by COVID-19
The purpose of this notice is to provide guidance outlining the flexibilities available to recipients conducting NIH-funded clinical trials and human subject studies, that are impacted by the declared public health emergency for COVID-19.

NIH Guidance for NIH-funded Clinical Trials and Human Subjects Studies Affected by COVID-19

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