Recent Publications
Putting the “Optimal” in Optimal Medical Therapy
Despite rigorous data supporting the benefits of optimal medical therapy (OMT) as recommended by the guidelines for patients with heart failure (HF) with reduced ejection fraction, the implementation and maximization of these therapies in the “real world” continues to be challenging.
Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel
The coronavirus disease-2019 (COVID-19) pandemic has profoundly changed clinical care and research, including the conduct of clinical trials, and the clinical research ecosystem will need to adapt to this transformed environment.
Utility of Restricted Mean Survival Time Analysis for Heart Failure Clinical Trial Evaluation and Interpretation
The study sought to demonstrate the statistical and utilitarian properties of restricted mean survival time
(RMST) and restricted mean time lost (RMTL) for assessing treatments for heart failure (HF) with reduced ejection fraction.
Design of a “Lean” Case Report Form for Heart Failure Therapeutic Development
The article published in JACC details the creation of a core CRF electronic form which is now freely available for use in clinical trials to improve clinical trial efficiency in HF drug and device development in the United States.